Stefanie Schwinn
graduated from the Federal Research Assistant School in Würzburg. Thereafter she joined the group of PD Dr. Wölfl as a research assistant and worked on new T-cell based Therapy against brain tumor. In 2012 she joined the Experimental Stem Cell Transplantation laboratory at Würzburg University as a research assistant with a focus on preclinical multiple myeloma models.
In October 2013 she was selected for a competitive slot to study medicine at the Julius-Maximilians-University in Würzburg. Recently she has started her medical thesis to develop novel therapeutic strategies for the treatment of group-3 medulloblastoma in children in close collaboration with PD Dr. Matthias Wölfl from the Department of Pediatrics. To achieve this goal she is also employing an orthotopic mouse model, which had been established in Würzburg from a young patient. She was awarded with a scholarship from the Manfred-Lautenschläger-Stiftung to support her pediatric-oncology research and is currently a supported through the Dean’s graduation fellowship program of Würzburg University Medical School (GSLS Promotionsstipendium).
Contact information:
Stefanie Schwinn, MD student
Tel: +49-931-201 27638
Publications:
Schwinn S, Mokhtari Z, Thusek S, Schneider T, Sirén AL, Tiemeyer N, Caruana I, Miele E, Schlegel PG, Beilhack A, Wölfl M. Cytotoxic effects and tolerability of gemcitabine and axitinib in a xenograft model for c-myc amplified medulloblastoma. Sci Rep, in press
Chopra M, Biehl M, Steinfatt T, Brandl A, Kums J, Amich J, Vaeth M, Kuen J, Holtappels R, Podlech J, Mottok A, Kraus S, Jordán Garrote AL, Bäuerlein CA, Brede C, Ribecchini E, Fick A, Seher A, Polz J, Ottmüller K, Baker J, Nishikii H, Ritz M, Mattenheimer K, Schwinn S, Winter T, Schäfer V, Krappmann S, Einsele H, Mueller TD, Reddehase MJ, Lutz MB, Männel DN, Berberich-Siebelt F, Wajant H, Beilhack A. (2016). Exogenous TNFR2 activation protects from acute GvHD by induction of host Treg expansion. J Exp Med 213:1881–1900.
Dietl S, Schwinn S, Dietl S, Riedel SS, Deinlein F, Rutkowski S, von Bueren AO, Krauss J, Vince GH, Eyrich M, Remke M, Monoranu C, Beilhack A, Schlegel PG, Wölfl M. (2016). An orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3- properties. BMC Cancer. 16(1):115
Chopra M, Brandl A, Siegmund D, Mottok A, Schäfer V, Biehl M, Kraus S, Bäuerlein CA, Ritz M, Mattenheimer K, Schwinn S, Seher A, Grabinger T, Einsele H, Rosenwald A, Brunner T, Beilhack A, Wajant H. (2015). Blocking TWEAK-Fn14 interaction inhibits hematopoietic stem cell transplantation-induced intestinal cell death and reduces GvHD. Blood 126(4):437-444.
Chandran PA, Keller A, Weinmann L, Adel Seida A, Braun M, Andreev K, Fischer B, Horn E, Schwinn S, Junker M, Houben R, Dombrowski Y, Dietl J, Finotto S, Wölfl M, Meister G, Wischhusen J. (2014). The TGF-β-inducible miR-23a cluster attenuates IFN-γ levels and antigen-specific cytotoxicity in human CD8+ T cells. J Leukoc Biol. 96(4):633-645.
Chopra M, Kraus S, Schwinn S, Ritz M, Mattenheimer K, Mottok A, Rosenwald A, Einsele H, Beilhack A. (2013). Non-invasive bioluminescence imaging to monitor the immunological control of a plasmablastic lymphoma-like B cell neoplasia after hematopoietic cell transplantation. PLoS One. 8(12):e81320.
Chopra M, Lang I, Salzmann S, Pachel C, Kraus S, Bäuerlein CA, Brede C, Garrote AL, Mattenheimer K, Ritz M, Schwinn S, Graf C, Schäfer V, Frantz S, Einsele H, Wajant H, Beilhack A. (2013). Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS One. 8(9):e75737.
Wölfl M, Schwinn S, Yoo YE, Reß ML, Braun M, Chopra M, Schreiber SC, Ayala VI, Ohlen C, Eyrich M, Beilhack A, Schlegel PG. (2013). Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis. Blood. 122(7):1203-1213.