Michael Kern

joined the Experimental Stem Cell Transplantation Lab initially for his MD thesis in 2019 and continued as a postdoctoral researcher after graduating from Würzburg Medical School in 2023. Prior to this, he earned his BSc in Molecular Medicine from the University of Regensburg, where he worked on conserved ribosomal mutants and ribosomal biogenesis in Archaea. He began his medical studies at Würzburg in 2016.

Currently, in the Beilhack Lab, Michael Kern is investigating the role of myeloid cells in modulating Graft-versus-Host Disease (GvHD), a frequent complication following allogeneic hematopoietic cell transplantation (allo-HCT). Additionally, he is exploring the impact of the microbiome on GvHD development and its influence on tissue-resident myeloid cells. His research aims to identify new therapeutic targets for preventing GvHD.

Contact:

Michael Kern

Postdoctoral research fellow

Tel: +49-931-201 27638

Kern_M4@ukw.de

Publications:

Shaikh H, Pezoldt J, Mokhtari Z, Gamboa Vargas J, Le DD, Peña Mosca J, Arellano Viera E, Kern MAG, Graf C, Beyersdorf N, Lutz MB, Riedel A, Büttner-Herold M, Zernecke A, Einsele H, Saliba AE, Ludewig B, Huehn J, Beilhack A. (2022). Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells. JCI Insight 7(22):e154250.

Kern M, Ferreira-Cerca S. (2022). Differential Translation Activity Analysis Using Biorthogonal Noncanonical Amino Acid Tagging (BONCAT) in Archaea. Methods Mol Biol 2533:229-246.

Jüttner M, Weiß M, Ostheimer N, Reglin C, Kern M, Knüppel R, Ferreira-Cerca S. (2020). A versatile cis-acting element reporter system to study the function, maturation and stability of ribosomal RNA mutants in archaea. Nucleic Acids Res 48(4):2073-2090.

Knüppel R, Trahan C, Kern M, Wagner A, Grünberger F, Hauser W, Quax T.E.F., Albers S.-V., Oeffinger M and Ferreira-Cerca S. (2021). Insights into synthesis and function of KsgA/Dim1-dependent rRNA modifications in archaea. Nucleic Acids Res 49(3):1662-1687. 

Awards and Stipends:

MD Fellowship Program of the German Research Council (DFG) International Research Training Group (IRTG) of CRC 221, “Modulation of GvH and GvL immune responses after allogeneic stem cell transplantation“, Regensburg – Erlangen – Würzburg

MD Excellence Program of the Graduate School of Live Sciences Würzburg