Haroon Shaikh
graduated in biotechnology from University of Karachi, Pakistan with distinction. After successfully completing his MSc, he worked as a researcher at Aga Khan University Hospital, Karachi, Pakistan. During his time at Aga Khan University, he was involved in a project on the Hepatitis C virus (HCV) replicon system and in a project investigating the role of androgen receptor in expanding the pool of cancer stem cells (CSC) of breast cancer.
From March 2015 until March 2016 he was a researcher at the Universitätsklinikum Magdeburg, where he investigated the role of Activated protein C (APC) on T-cell signaling and T-cell migration in a mouse contact dermatitis model utilizing intravital two-photon laser scanning microscopy.
Haroon joined the Beilhack in July 2016 as a doctoral student and graduated in 2021. During his PhD qualification phase he has been selected for a scholarship of the DFG graduate training program 3D Infect. He explores antigen recognition of alloreactive T cells in GvHD target tissues and anti-leukemia immune recognition in acute myeloid leukemia (AML). Recently he became a young investigator in the DFG TRR221 GvH-GvL research consortium.
Contact:
Haroon Shaikh, PhD
Postdoctoral research fellow
Tel: +49-931-201 27638
Shaikh_H@ukw.de
Publications
Daud M, Dasari P, Adelfinger M, Langenhorst D, Lother J, Slavkovic-Lukic D, Berges C, Kruhm M, Galler A, Schleussner C, Luther CH, Alberter K, Althammer A, Shaikh H, Pallmann N, Bodem J, El-Mowafy M, Beilhack A, Dittrich M, Topp MS, Zipfel PF, Beyersdorf N. (2023). Enolase 1 of Candida albicans binds human CD4+ T cells and modulates naïve and memory responses. Eur J Immunol e2250284 (doi: 10.1002/eji.202250284).
Shaikh H, Pezoldt J, Mokhtari Z, Gamboa Vargas J, Le DD, Peña Mosca J, Arellano Viera E, Kern MAG, Graf C, Beyersdorf N, Lutz MB, Riedel A, Büttner-Herold M, Zernecke A, Einsele H, Saliba AE, Ludewig B, Huehn J, Beilhack A. (2022). Fibroblastic reticular cells mitigate acute GvHD via MHCII-dependent maintenance of regulatory T cells. JCI Insight 7(22):e154250.
Ataide MA*, Knöpper K*, Cruz de Casas P*, Ugur M, Eickhoff S, Zou M, Shaikh H, Trivedi A, Grafen A, Yang T, Prinz I, Ohlsen K, Gomez de Agüero M, Beilhack A, Huehn J, Gaya M, Saliba AE, Gasteiger G, Kastenmüller W. Lymphatic migration of unconventional T cells promotes site-specific immunity in distinct lymph nodes. Immunity, 55(10):1813-1828.e9.
Shaikh H, Beilhack A. (2022). GvHD: pDCs providing VIP protection. Blood 140(12):1333-1334.
Gamboa Vargas J*, Wagner J*, Shaikh H, Lang I, Medler J, Anany M, Steinfatt T, Peña Mosca J, Haack S, Dahlhoff J, Büttner-Herold M, Graf C, Arellano E, Einsele H, Wajant H*, Beilhack A. (2022). A TNFR2-specific TNF fusion protein with improved in vivo activity. Front Immunol, 13:888274.
Shaikh H, Gamboa Vargas J, Mokhtari Z, Jarick KL, Ulbrich M, Peña Mosca J, Le DD, Heinze KG, Büttner-Herold M, Rosenwald A, Pezoldt J, Huehn J, Beilhack A. (2021). Mesenteric lymph node transplantation in mice to study immune responses of the gastrointestinal tract. Front Immunol 12:689896.
Jarick KJ, Mokhtari Z, Scheller L, Hartweg J, Thusek S, Le DD, Ranecky M, Shaikh H, Qureischi M, Heinze KG, Beilhack A. (2018). Photoconversion of Alloreactive T Cells in Murine Peyer’s Patches During Acute Graft-Versus-Host Disease: Tracking the Homing Route of Highly Proliferative Cells In Vivo. Front. Immunol. 9:1468.
Ranjan, S, Goihl A, Kohli S, Gadi I, Pierau M, Shahzad K, Gupta D, Bock F, Wang H, Shaikh H, Kähne T, Reinhold D, Niemz J, Schnöder T, Brunner-Weinzierl M, Fischer T, Kalinski T, Schraven B, Luft T, Huehn J, Naumann M, Heidel F, Isermann B (2017). Activated protein C protects from GvHD via PAR2/PAR3 signalling in regulatory T-cells. Nature Communications 8(1): 311.