Ana-Laura Jordán Garrote, PhD

Ana-Laura Jordán Garrote, PhD, GVHD, immunoregulation, immunotherapy, Immuntherapie Würzburg
graduated in biology at the University of Barcelona, Spain. She conducted her PhD thesis research project in the Experimental Stem Cell Transplantation laboratory and was awarded a prestigious Graduate School of Life Sciences Fellowship of the German Excellence Initiative. In her PhD thesis project she investigated the role of dendritic cells (DCs) in intestinal acute graft-versus-host disease (aGVHD). To accomplish this goal she employed a variety of methods such as in vivo bioluminescence imaging (BLI), fluorescence microscopy, multiparameter flow cytometry, cell sorting and multiplex cytokine analysis, among others. Throughout her PhD time she was member of the Graduate College “Immunomodulation” and actively pursued several successful national and international collaborations, including a research visit at Harvard University in 2014. She completed her PhD Thesis in 2014 (Summa cum Laude). Since then she continues her research in allogeneic hematopoietic cell transplantation as a postdoctoral fellow and is in charge of the GvHD core in the Beilhack lab.

Contact:

Dr. Ana-Laura Jordán Garrote

Postdoctoral Fellow

Tel:   +49-931-201 27638

Jordan_A@ukw.de

 

Fellowships and Awards

2009: STIBET-fellowship from the German Academic Exchange Programme (DAAD).

2010-2014: Fellowship from the German Excellence Initiative at the Graduate School of Life Sciences, University of Würzburg.

2013: First poster award “Else-Kröner symposium, Translational Immunology – from Target to Therapy”, (Würzburg, Germany).

2015: First poster award “Else-Kröner symposium, Translational Immunology – from Target to Therapy”, (Würzburg, Germany)

 

Publications

Ribechini E, Hutchinson JA, Hergovits S, Heuer M, Lucas J, Schleicher U, Jordán Garrote AL, Potter SJ, Riquelme P, Brackmann H, Müller N, Raifer H, Berberich I, Huber M, Beilhack A, Lohoff M, Bogdan C, Eyrich M, Hermanns H, Geissler EK, Lutz MB. (2017). Novel GM-CSF signals via IFNgR/IRF-1 and AKT/mTOR license monocytes. Blood Advances 1:947-960.

Chopra M, Biehl M, Steinfatt T, Brandl A, Kums J, Amich J, Vaeth M, Kuen J, Holtappels R, Podlech J, Mottok A, Kraus S, Jordán Garrote AL, Bäuerlein CA, Brede C, Ribecchini E, Fick A, Seher A, Polz J, Ottmüller K, Baker J, Nishikii H, Ritz M, Mattenheimer K, Schwinn S, Winter T, Schäfer V, Krappmann S, Einsele H, Mueller TD, Reddehase MJ, Lutz MB, Männel DN, Berberich-Siebelt F, Wajant H, Beilhack A. (2016). Exogenous TNFR2 activation protects from acute GvHD by induction of host Treg expansion. J Exp Med 213:1881–1900.

Distler E, Albrecht J, Brunk A, Khan S, Schnürer E, Frey M, Mottok A, Jordán Garrote AL, Brede C, Beilhack A, Mades A, Tomsitz D, Theobald M, Herr W, Hartwig UF. (2016). Patient-individualized CD8+ cytolytic T-cell therapy effectively combats minimal residual leukemia in immunodeficient mice. Int J Cancer 138(5):1256-1268.

Chopra M, Lang I, Salzmann S, Pachel C, Kraus S, Bäuerlein C, Brede C, Jordán Garrote AL, Mattenheimer K, Ritz M, Schwinn S, Graf C, Schäfer V, Frantz S, Einsele H, Wajant H, Beilhack A. (2013). Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1. PLoS ONE 8(9): e75737.

Bäuerlein CA, Riedel SS, Baker J, Brede, C, Jordán Garrote AL, Ritz M, Schulz S, Grether M, Chopra M, Beilhack GF, Zeiser R, Schlegel PG, Einsele H, Negrin RS, Beilhack A. (2013). A diagnostic window for the treatment of acute GVHD prior to visible clinical symptoms in a murine model. BMC Medicine 11(1): 134.

Chopra M, Riedel SS, Biehl M, Donat S, von Krosigk V, Bäuerlein CA, Brede C, Jordan-Garrote AL, Schäfer V, Ritz M, Mattenheimer K, Degla A, Mottok A, Einsele H, Wajant H, Beilhack A. (2013). Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as player in TNF-induced experimental metastasis. Carcinogenesis 34(6): 1296-1303.

Brede C, Friedrich M, Jordán-Garrote AL, Riedel SS, Bäuerlein CA, Heinze K, Bopp T, Schulz S, Mottok A, Kiesel C, Mattenheimer K, Ritz M, von Krosigk V, Rosenwald A, Einsele H, Negrin RS, Harms GS, Beilhack A. (2012) Mapping immune processes in intact tissues at cellular resolution. Journal of Clinical Investigation 122 (12): 4439-4446.

Riedel SS, Mottok A, Brede C, Bäuerlein CA, Jordán Garrote AL, Ritz M, Mattenheimer K, Rosenwald A, Einsele, H, Bogen B, Beilhack A. (2012). Non-invasive imaging provides spatiotemporal information on disease progression and response to therapy in a murine model of multiple myeloma. PLoS ONE 7: e52398.