Illustration Reciprocal regulation of JAM-C & CD138 Brandl A. et al. Blood Advances 2022

Junctional Adhesion Molecule C, JAM-C (JAM-3) responsible for MM dissemination. JAM-C positive multiple myeloma cells down regulate CD138. JAM-C identifies CD138 negative myeloma cells, which would be missed in analyses after CD138 enrichment. Andreas Beilhack laboratory at Immunotherapy program at Würzburg University, Germany, NCT WERA National Cancer Center

JAM-C promotes MM dissemination. JAM-C positive multiple myeloma cells downregulate CD138 and enhance migratory behavior. Brandl A. et al. Blood Advances 2022