“STAR2-Treg” – New strategy to limit side effects of stem cell transplants

The Journal of Experimental Medicine 2016 CoverOur lab has developed a new approach that may prevent leukemia and lymphoma patients from developing graft-versus-host disease (GvHD) after therapeutic bone marrow transplants. Acute GvHD can be a life-threatening immune reaction following transplantation. In an article by Martin Chopra et al. we describe the successful application of the strategy in mice in our recent paper “Exogenous TNFR2 activation protects from acute GvHD via host regulatory T cell expansion” that is now published in The Journal of Experimental Medicine.


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